Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats

Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats

Abstract Background Retinal neurodegeneration is induced by a variety of environmental insults and stresses, but the exact mechanisms are unclear. In the present study, we explored the involvement of cytosolic mitochondrial DNA (mtDNA), resulting in the cGAS-STING dependent inflammatory response and...

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Bibliographic Details
Main Authors: Yue Guo, Dekang Gan, Fangyuan Hu, Yun Cheng, Jian Yu, Boya Lei, Qinmeng Shu, Ruiping Gu, Gezhi Xu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Biological Research
Subjects:
Mitochondrial DNA
cGAS–STING
Apoptosis
Retina
Online Access:https://doi.org/10.1186/s40659-022-00390-6

Internet

https://doi.org/10.1186/s40659-022-00390-6

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