Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets

Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets

<i>FLT3</i>-mutant acute myeloid leukemia (AML) is an aggressive form of leukemia with poor prognosis. Treatment with <i>FLT3</i> inhibitors frequently produces a clinical response, but the disease nevertheless often recurs. Recent studies have revealed system-wide gene expre...

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Bibliographic Details
Main Authors: David J. Wooten, Melat Gebru, Hong-Gang Wang, Réka Albert
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Personalized Medicine
Subjects:
acute myeloid leukemia
Boolean model
drug resistance
network
Online Access:https://www.mdpi.com/2075-4426/11/3/193

Internet

https://www.mdpi.com/2075-4426/11/3/193

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