Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed inside a cell to target intracellular antigens. In the context of intracellular protein misfolding and aggregation, such as tau pathology in A...

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Bibliographic Details
Main Authors: Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theunis
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
tau
intrabodies
aggregation
scFv
CDR grafting
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001973

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http://www.sciencedirect.com/science/article/pii/S2329050123001973

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