A transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome induced pluripotent stem cells

A transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome induced pluripotent stem cells

Objective: The transcriptional landscape of Klinefelter syndrome (KS) during early embryogenesis remains elusive. This study aimed to evaluate the impact of X chromosome overdosage in 47,XXY males induced pluripotent stem cells (iPSCs) obtained from patients with different genomic backgrounds and et...

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Main Authors: Veronica Astro, Elisabetta Fiacco, Kelly Johanna Cardona-Londoño, Ilario De Toma, Hams Saeed Alzahrani, Jumana Alama, Amal Kokandi, Taha Abo-Almagd Abdel-Meguid Hamoda, Majed Felemban, Antonio Adamo
Format: Article
Language:English
Published: Bioscientifica 2023-05-01
Series:Endocrine Connections
Subjects:
klinefelter syndrome
x chromosome
pseudoautosomal region
escape genes
induced pluripotent stem cells
Online Access:https://ec.bioscientifica.com/view/journals/ec/12/5/EC-22-0515.xml

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https://ec.bioscientifica.com/view/journals/ec/12/5/EC-22-0515.xml

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