Pan-cancer and single-cell analyses identify CD44 as an immunotherapy response predictor and regulating macrophage polarization and tumor progression in colorectal cancer

Pan-cancer and single-cell analyses identify CD44 as an immunotherapy response predictor and regulating macrophage polarization and tumor progression in colorectal cancer

IntroductionCluster of differentiation (CD) 44 is a non-kinase cell surface transmembrane glycoprotein critical for tumor maintenance and progression.MethodsWe conducted a systematic analysis of the expression profile and genomic alteration profile of CD44 in 33 types of cancer. The immune character...

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Bibliographic Details
Main Authors: Qian Zhang, Xinyu Wang, Yang Liu, Hao Xu, Chun Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Oncology
Subjects:
CD44
pan cancer
immunotherapy
macrophages
colorectal (colon) cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1380821/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1380821/full

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