Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcoichinol-O-Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model

Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcoichinol-O-Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model

Tumor vasculature is an attractive therapeutic target as it differs structurally from normal vasculature, and the destruction of a single vessel can lead to the death of many tumor cells. The effects of antivascular drugs are frequently short term, with regrowth beginning less than 24 hours posttrea...

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Bibliographic Details
Main Authors: Dominick J.O. McIntyre, Simon P. Robinson, Franklyn A. Howe, John R. Griffiths, Anderson J. Ryan, David C. Blakey, Ian S. Peers, John C. Waterton
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ZD6126
vascular targeting
therapy
cancer
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800617

Internet

http://www.sciencedirect.com/science/article/pii/S1476558604800617

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