Proliferation extent of CD34+ cells as a key parameter to maximize megakaryocytic differentiation of umbilical cord blood-derived hematopoietic stem/progenitor cells in a two-stage culture protocol

Proliferation extent of CD34+ cells as a key parameter to maximize megakaryocytic differentiation of umbilical cord blood-derived hematopoietic stem/progenitor cells in a two-stage culture protocol

Co-infusion of ex-vivo generated megakaryocytic progenitors with hematopoietic stem/progenitor cells (HSC/HPC) may contribute to a faster platelet recovery upon umbilical cord blood (UCB) transplantation. A two stage protocol containing cell expansion and megakaryocyte (Mk) differentiation was estab...

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Bibliographic Details
Main Authors: Javad Hatami, Pedro Z. Andrade, Denise Bacalhau, Fernando Cirurgião, Frederico Castelo Ferreira, Joaquim M.S. Cabral, Cláudia L. da Silva
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Biotechnology Reports
Subjects:
Megakaryocytic differentiation
Platelets
Megakaryocytes
Hematopoietic stem/progenitor cells
Umbilical cord blood
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X14000253

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http://www.sciencedirect.com/science/article/pii/S2215017X14000253

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