Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/β-catenin signaling pathway and analysis of active ingredients by molecular docking

Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/β-catenin signaling pathway and analysis of active ingredients by molecular docking

Background: Sea buckthorn (SBT) is a traditional Chinese medicine (TCM), rich in calcium, phosphorus, and vitamins, which can potentially prevent and treat osteoporosis. However, no research has been conducted to confirm these hypotheses. QiangGuYin (QGY) is a TCM compound used to treat osteoporosis...

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Bibliographic Details
Main Authors: Yi-Feng Yuan, Shen Wang, Hang Zhou, Bin-Bin Tang, Yang Liu, Hai Huang, Cai-Jian He, Tian-Peng Chen, Mou-Hao Fang, Bo-Cheng Liang, Ying-De-Long Mao, Feng-Qin Qie, Kang Liu, Xiao-Lin Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
sea buckthorn
postmenopausal osteoporosis
Notum
CKIP-1
Wnt/β-catenin signaling pathway
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.994995/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.994995/full

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