Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation

Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation

Abstract Background Chronic kidney disease (CKD) involves a variety of pathological processes, and ferroptosis plays a vital role in CKD progression. Targeting ferroptosis is a promising strategy for the treatment of CKD. However, inhibitors of ferroptosis have not been used in the clinical treatmen...

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Bibliographic Details
Main Authors: Jiayu Song, Hongri Wang, Jingyi Sheng, Wen Zhang, Juan Lei, Weihua Gan, Fangfang Cai, Yunwen Yang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Medicine
Subjects:
Vitexin
Ferroptosis
CKD
NRF2
Antioxidant
Online Access:https://doi.org/10.1186/s10020-023-00735-1

Internet

https://doi.org/10.1186/s10020-023-00735-1

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