Glial and tissue-specific regulation of Kynurenine Pathway dioxygenases by acute stress of mice

Stressors activate the hypothalamic-pituitary-adrenal (HPA) axis and immune system eliciting changes in cognitive function, mood and anxiety. An important link between stress and altered behavior is stimulation of the Kynurenine Pathway which generates neuroactive and immunomodulatory kynurenines. T...

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Bibliographic Details
Main Authors: Carlos R. Dostal, Megan Carson Sulzer, Keith W. Kelley, Gregory G. Freund, Robert H. McCusker
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289516300492