Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila

Abstract Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson’s disease (PD), a disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. However, the causal role of circadian clocks in the degenerative process remains uncertain. W...

Full description

Bibliographic Details
Main Authors: Michaëla Majcin Dorcikova, Lou C. Duret, Emma Pottié, Emi Nagoshi
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41540-y