Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

Abstract Background Astrocyte activation is a hallmark of traumatic brain injury resulting in neurological dysfunction or death for an overproduction of inflammatory cytokines and glial scar formation. Both the silent mating type information (Sirt1) expression and mitogen-activated protein kinase (M...

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Bibliographic Details
Main Authors: Dan Li, Nan Liu, Hai-Hua Zhao, Xu Zhang, Hitoshi Kawano, Lu Liu, Liang Zhao, Hong-Peng Li
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Journal of Neuroinflammation
Subjects:
Brain injury
Sirt1
ERK pathway
JNK pathway
p38MAPK pathway
Astrocyte activation
Online Access:http://link.springer.com/article/10.1186/s12974-017-0841-6

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http://link.springer.com/article/10.1186/s12974-017-0841-6

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