Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensional approaches to genetic discovery for the first...

Full description

Bibliographic Details
Main Authors: Travis T. Mallard, Richard Karlsson Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Genomics
Subjects:
psychiatric genetics
psychiatric disorders
transdiagnostic
genome-wide association study
genetic correlation
pleiotropy
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22000738

Internet

http://www.sciencedirect.com/science/article/pii/S2666979X22000738

Similar Items