Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies

Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies

The emergence of very large cohorts in genomic research has facilitated a focus on genotype-imputation strategies to power rare variant association. These strategies have benefited from improvements in imputation methods and association tests, however little attention has been paid to ways in which...

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Bibliographic Details
Main Authors: Genevieve L. Wojcik, Christian Fuchsberger, Daniel Taliun, Ryan Welch, Alicia R Martin, Suyash Shringarpure, Christopher S. Carlson, Goncalo Abecasis, Hyun Min Kang, Michael Boehnke, Carlos D. Bustamante, Christopher R. Gignoux, Eimear E. Kenny
Format: Article
Language:English
Published: Oxford University Press 2018-10-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Genomics
Statistical Genetics
Imputation
tag SNPs
array design
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200502

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200502

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