Local injection of BDNF producing mesenchymal stem cells increases neuronal survival and synaptic stability following ventral root avulsion

Local injection of BDNF producing mesenchymal stem cells increases neuronal survival and synaptic stability following ventral root avulsion

The present study proposed to graft mesenchymal stem cells (MSCs), which continuously produce BDNF, into the spinal cord ventral horn, after ventral root avulsion. Neurotrophin expression was naturally achieved by culturing MSCs in an undifferentiated state for at least 10 weeks. Lewis rats were sub...

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Bibliographic Details
Main Authors: Rafaela Chitarra Rodrigues Hell, Miriam Maria Silva Costa, Alfredo Miranda Goes, Alexandre L.R. Oliveira
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
Stem cells
Motoneuron
Spinal cord
Ventral root avulsion
Glial reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002660

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http://www.sciencedirect.com/science/article/pii/S0969996108002660

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