Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita

Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita

Stress-induced heat shock protein 70 (Hsp70) is a key intra- and extracellular molecular chaperone implicated in autoimmune processes. Highly immunogenic extracellular Hsp70 can activate innate and acquired (adaptive) immune responses driving the generation of anti-Hsp70 autoantibodies that are freq...

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Bibliographic Details
Main Authors: Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
autoimmune bullous diseases (AIBDs)
epidermolysis bullosa acquisita (EBA)
heat shock proteins (Hsps)
Hsp70
autoantibodies
nuclear factor kappa B (NF-κB)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.877958/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.877958/full

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