Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility

Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility

Phosphodiesterase (PDE) inhibitors can improve sperm motility in patients with asthenozoospermia. However, the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadvantages of requiring a high concentration and destroying sperm integrity. We ex...

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Bibliographic Details
Main Authors: Yi-Ting Yang, Bin Yan, Yu-Hua Li, Li-Na Guo, Wei-Wei Wang, Li-Jie Liu, He-Guo Yu, Hua Diao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Asian Journal of Andrology
Subjects:
pentoxifylline; phosphodiesterase 10a; sildenafil; sperm motility; spontaneous acrosome reaction
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=5;spage=608;epage=615;aulast=Yang

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=5;spage=608;epage=615;aulast=Yang

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