Ex Vivo Blockade of the PD-1 Pathway Improves Recall IFNγ Responses of HIV-Infected Persons on Antiretroviral Therapy

Ex Vivo Blockade of the PD-1 Pathway Improves Recall IFNγ Responses of HIV-Infected Persons on Antiretroviral Therapy

Despite antiretroviral therapy (ART), immune exhaustion persists in HIV infection and limits T cell responses to HIV or other pathogens. Moreover, HIV infection results in the loss of pre-existing immunity. Here, we investigated the effect of blocking the PD-1 pathway on recall IFNγ responses to tet...

Full description

Bibliographic Details
Main Authors: Natalie Fischhaber, Moritz Schmiedeberg, Sabrina Kübel, Ellen G. Harrer, Thomas Harrer, Krystelle Nganou-Makamdop
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Vaccines
Subjects:
T cell exhaustion
PD-1 pathway
HIV infection
vaccine-induced immunity
anti-PD-1
anti-PD-L1
Online Access:https://www.mdpi.com/2076-393X/11/2/211

Internet

https://www.mdpi.com/2076-393X/11/2/211

Similar Items