Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly

Abstract Actin filament turnover involves subunits binding to and dissociating from the filament ends, with the pointed end being the primary site of filament disassembly. Several molecules modulate filament turnover, but the underlying mechanisms remain incompletely understood. Here, we present thr...

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Bibliographic Details
Main Authors: Micaela Boiero Sanders, Wout Oosterheert, Oliver Hofnagel, Peter Bieling, Stefan Raunser
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52251-3