Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells

Chronic hyperglycemia and hyperlipidemia hamper beta cell function, leading to glucolipotoxicity. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes, such as methylglyoxal (MG) and 4-hydroxynonenal (4-HNE), derived from glucose and lipids, respectively. We aimed to investig...

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Bibliographic Details
Main Authors: Shiau-Mei Chen, Siow-Wey Hee, Shih-Yun Chou, Meng-Wei Liu, Che-Hong Chen, Daria Mochly-Rosen, Tien-Jyun Chang, Lee-Ming Chuang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomolecules
Subjects:
aldehyde dehydrogenase 2 (ALDH2)
glucolipotoxicity
beta cell function
Alda-1
Online Access:https://www.mdpi.com/2218-273X/11/10/1474

Internet

https://www.mdpi.com/2218-273X/11/10/1474

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