Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment options, such as triple-negative breast cancer (TNBC), to chemo- and/or radiotherapy. Dichloroacetate (DCA) is a specific inhibitor of the pyr...

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Bibliographic Details
Main Authors: Sven de Mey, Inès Dufait, Heng Jiang, Cyril Corbet, Hui Wang, Melissa Van De Gucht, Lisa Kerkhove, Ka Lun Law, Hugo Vandenplas, Thierry Gevaert, Olivier Feron, Mark De Ridder
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
dichloroacetate
hypoxic radiosensitivity
breast cancer
reactive oxygen species
Online Access:https://www.mdpi.com/1422-0067/21/24/9367

Internet

https://www.mdpi.com/1422-0067/21/24/9367

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