Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

Abstract Background A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon-γ (IFN-γ)/ Janus kinase (JAK)/ signal transducer and activator of transcription (STAT)1 pat...

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Main Authors: Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu, Kun-Huei Yeh
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Biomedical Science
Subjects:
Colorectal cancer
Major histocompatibility complex (MHC) class I
Proteasome inhibitors
STAT1
Tumor infiltrating lymphocytes (TILs)
Interferon-γ (IFN-γ)
Online Access:https://doi.org/10.1186/s12929-021-00769-9

Internet

https://doi.org/10.1186/s12929-021-00769-9

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