Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant <i>Klebsiella pneumoniae</i> in Rodents

Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant <i>Klebsiella pneumoniae</i> in Rodents

Antimicrobial-resistant (AMR) bacteria, such as <i>Klebsiella</i> species, are an increasingly common cause of hospital-acquired pneumonia, resulting in high mortality and morbidity. Harnessing the host immune response to AMR bacterial infection using mesenchymal stem cells (MSCs) is a p...

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Bibliographic Details
Main Authors: Declan Byrnes, Claire H. Masterson, Hector E. Gonzales, Sean D. McCarthy, Daniel P. O’Toole, John G. Laffey
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells
pneumonia
inflammation
preactivation
multiple doses
Online Access:https://www.mdpi.com/1422-0067/24/9/8055

Internet

https://www.mdpi.com/1422-0067/24/9/8055

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