Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination

Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination

Abstract Background This clinical trial evaluated a novel telomerase-targeting therapeutic cancer vaccine, UV1, in combination with ipilimumab, in patients with metastatic melanoma. Translational research was conducted on patient-derived blood and tissue samples with the goal of elucidating the effe...

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Bibliographic Details
Main Authors: Espen Basmo Ellingsen, Gergana Bounova, Iliana Kerzeli, Irantzu Anzar, Donjete Simnica, Elin Aamdal, Tormod Guren, Trevor Clancy, Artur Mezheyeuski, Else Marit Inderberg, Sara M. Mangsbo, Mascha Binder, Eivind Hovig, Gustav Gaudernack
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Translational Medicine
Subjects:
Cancer
Immunotherapy
Therapeutic Cancer Vaccine
Telomerase
hTERT
Melanoma
Online Access:https://doi.org/10.1186/s12967-022-03624-z

Internet

https://doi.org/10.1186/s12967-022-03624-z

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