Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease and there are numerous mechanisms driving cellular s...

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Bibliographic Details
Main Authors: Hillary H. Le, Suleyman S. Cinaroglu, Elise C. Manalo, Aysegul Ors, Michelle M. Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A. Origel Marmolejo, Arnaud Quentel, Justin S. Plaut, Taryn E. Kawashima, E. Sila Ozdemir, Sanjay V. Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C. Saldivar, Emel Timucin, Jared M. Fischer
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:EBioMedicine
Subjects:
Senolytic
FOXO4
TP53
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004394

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http://www.sciencedirect.com/science/article/pii/S2352396421004394

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