Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence

Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence

ABSTRACT The Gram-negative anaerobe Fusobacterium nucleatum is a major producer of hydrogen sulfide (H2S), a volatile sulfur compound that causes halitosis. Here, we dissected the genetic determinants of H2S production and its role in bacterial fitness and virulence in this important member of the o...

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Bibliographic Details
Main Authors: Yi-Wei Chen, Martha I. Camacho, Yimin Chen, Aadil H. Bhat, Chungyu Chang, Emily A. Peluso, Chenggang Wu, Asis Das, Hung Ton-That
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
Fusobacterium nucleatum
hydrogen sulfide
lanthionine
metabolism
virulence
preterm birth
Online Access:https://journals.asm.org/doi/10.1128/mbio.01936-22

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