Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcriptional regulators (TFRs) belonging to three genom...

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Bibliographic Details
Main Authors: Hang Wu, Yansheng Wang, Li Yuan, Yongrong Mao, Weiwei Wang, Lin Zhu, Panpan Wu, Chengzhang Fu, Rolf Müller, David T. Weaver, Lixin Zhang, Buchang Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2016-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Saccharopolyspora erythraea
Erythromycin
TetR family
SACE_3446
Regulatory network
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X15300077

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http://www.sciencedirect.com/science/article/pii/S2405805X15300077

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