Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol) unlike PDI inhibitor quercetin 3-rutinoside (Q3R)...

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Bibliographic Details
Main Authors: Abdul Burhan Khan, Neha Gupta, Qudsia Rashid, Irshad Ahmad, Shadabi Bano, Urfi Siddiqui, Mohammad Abid, Mohamad Aman Jairajpuri
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Medicine in Drug Discovery
Subjects:
Protein Disulfide Isomerase
Thrombosis
Quercetin
Coagulation
Novel anticoagulant
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098620300166

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http://www.sciencedirect.com/science/article/pii/S2590098620300166

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