Cortical Iron Regulation and Inflammatory Response in Alzheimer’s Disease and APPSWE/PS1ΔE9 Mice: A Histological Perspective
Disruption of iron homeostasis and increased glial response are known to occur in brains afflicted by Alzheimer’s disease (AD). While the APP/PS1 transgenic mouse model recapitulates the hallmark amyloid-beta plaque pathology of AD, it does so in a different neuronal mileu than humans. Understandi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00255/full |