Development of pre-clinical models for evaluating the therapeutic potential of candidate siRNA targeting STAT6.

Development of pre-clinical models for evaluating the therapeutic potential of candidate siRNA targeting STAT6.

Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. Here, we describe methodology that evaluates the su...

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Bibliographic Details
Main Authors: Gareth D Healey, Jennifer A Lockridge, Shawn Zinnen, Julian M Hopkin, Ivan Richards, William Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3937390?pdf=render

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http://europepmc.org/articles/PMC3937390?pdf=render

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