GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABAA receptors

GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABAA receptors

Summary: Striatal dopamine axons co-release dopamine and gamma-aminobutyric acid (GABA), using GABA provided by uptake via GABA transporter-1 (GAT1). Functions of GABA co-release are poorly understood. We asked whether co-released GABA autoinhibits dopamine release via axonal GABA type A receptors (...

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Bibliographic Details
Main Authors: Jyoti C. Patel, Ang D. Sherpa, Riccardo Melani, Paul Witkovsky, Madeline R. Wiseman, Brian O’Neill, Chiye Aoki, Nicolas X. Tritsch, Margaret E. Rice
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001621

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http://www.sciencedirect.com/science/article/pii/S2211124724001621

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