Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1

Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1

Alcoholic liver disease (ALD) results from continuous and heavy alcohol consumption. The current treatment strategy for ALD is based on alcohol withdrawal coupled with antioxidant drug intervention, which is a long process with poor efficacy and low patient compliance. Alcohol-induced CYP2E1 upregul...

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Bibliographic Details
Main Authors: Yalan Wang, Qiubing Chen, Shuang Wu, Xinyu Sun, Runting Yin, Zhen Ouyang, Hao Yin, Yuan Wei
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Alcoholic liver disease
RNAi
Lipid nanoparticle
Cyp2e1
Reactive oxygen species
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000096

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http://www.sciencedirect.com/science/article/pii/S2211383523000096

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