Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production

Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production

IntroductionGroup 3 innate lymphoid cells (ILC3s) are enriched in the intestinal mucosa and play important roles in host defense against infection and inflammatory diseases. Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD+)- dependent deacetylase and has been shown to control intestina...

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Bibliographic Details
Main Authors: Xiaohui Su, Linfeng Zhao, Huasheng Zhang, Dongdi Wang, Jiping Sun, Lei Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
sirtuin 6
group 3 innate lymphoid cells
IL-22
gut immunity
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402834/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402834/full

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