Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications

Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications

Succinate dehydrogenase gene (SDHx) mutations increase susceptibility to develop pheochromocytomas/paragangliomas (PHEOs/PGLs). In the present study, we evaluate the performance and clinical applications of 1H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy...

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Bibliographic Details
Main Authors: Alessio Imperiale, François-Marie Moussallieh, Philippe Roche, Stéphanie Battini, A. Ercument Cicek, Frédéric Sebag, Laurent Brunaud, Anne Barlier, Karim Elbayed, Anderson Loundou, Philippe Bachellier, Bernard Goichot, Constantine A. Stratakis, Karel Pacak, Izzie-Jacques Namer, David Taïeb
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614001687

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http://www.sciencedirect.com/science/article/pii/S1476558614001687

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