Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling

Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling

Abstract Background Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive. Methods To assess the requirement for SMAD4 in BMP4-mediated suppression of metast...

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Bibliographic Details
Main Authors: Lap Hing Chi, Andrew D. Redfern, Suraya Roslan, Ian P. Street, Allan D. Burrows, Robin L. Anderson
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Metastasis
BMP4
SMAD4
MYO1F
Patient outcomes
Online Access:https://doi.org/10.1186/s12964-024-01559-0

Internet

https://doi.org/10.1186/s12964-024-01559-0

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