Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients

Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients

Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil clusters in COVID-19, including the emergence of low density neutrophils (LDN) that are associated with severe disease. The functional capabiliti...

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Bibliographic Details
Main Authors: Kenneth R. McLeish, Rejeena Shrestha, Aruna Vashishta, Madhavi J. Rane, Michelle T. Barati, Michael E. Brier, Mario Gutierrez Lau, Xiaoling Hu, Oscar Chen, Caitlin R. Wessel, Travis Spalding, Sarah E. Bush, Kenechi Ijemere, C. Danielle Hopkins, Elizabeth A. Cooke, Shweta Tandon, Terri Manning, Silvia M. Uriarte, Jiapeng Huang, Jun Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
neutrophil
COVID-19
low density neutrophil
respiratory burst
exocytosis
NET formation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.879686/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.879686/full

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