Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma

Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma

BackgroundOral cavity squamous cell carcinoma (OSCC) is an aggressive malignant tumor with high recurrence and poor prognosis in the advanced stage. Patient-derived xenografts (PDXs) serve as powerful preclinical platforms for drug testing and precision medicine for cancer therapy. We assess which m...

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Bibliographic Details
Main Authors: Wei-Chen Yen, Ian Yi-Feng Chang, Kai‐Ping Chang, Chun‐Nan Ouyang, Chiao-Rou Liu, Ting-Lin Tsai, Yi-Cheng Zhang, Chun-I Wang, Ya-Hui Wang, Alice L. Yu, Hsuan Liu, Chih-Ching Wu, Yu-Sun Chang, Jau-Song Yu, Chia-Yu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
patient-derived xenografts
oral cavity squamous cell carcinoma
whole-exome sequencing
transcriptome sequencing
engraftment ability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.792297/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.792297/full

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