Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes

Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes

Myocardial ischemic/reperfusion injury results from severe impairment of coronary blood supply and leads to irreversible cell death, with limited therapeutic possibilities. Asiatic acid is a pentacyclic triterpenoid derived from the tropical medicinal plant Centella asiatica and serves a variety of...

Full description

Bibliographic Details
Main Authors:	Xiang Huang, Li Zuo, Yanni Lv, Chuqiao Chen, Yaqin Yang, Hongbo Xin, Yunman Li, Yisong Qian
Format:	Article
Language:	English
Published:	MDPI AG 2016-09-01
Series:	Molecules
Subjects:	asiatic acid myocardial ischemia OGD/R Akt HIF-1α
Online Access:	http://www.mdpi.com/1420-3049/21/9/1248

Similar Items

THE ASIATIC SPECIES OF PERSEA Mill. (Lauraceae)
by: A.J.G.H Kostermans
Published: (2014-01-01)

Asiatic acid affects the growth of human osteosarcoma cells by regulating PI3K/AKT and NF-κB dual signal pathways
by: Yanran Huang, et al.
Published: (2023-12-01)

JMJD5 attenuates oxygen–glucose deprivation and reperfusion‐induced injury in cardiomyocytes through regulation of HIF‐1α‐BNIP3
by: Ya‐Nan Zhang, et al.
Published: (2022-01-01)

Modul de productie asiatic – dezbateri teoretice
by: Valentin Quintus NICOLESCU
Published: (2016-12-01)

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
by: Na Liu, et al.
Published: (2020-05-01)

Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R
by: Ruheng Wei, et al.
Published: (2022-11-01)

Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
by: Lei Z, et al.
Published: (2020-04-01)

The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats
by: Andrzej Wróbel, et al.
Published: (2021-05-01)

Can mtDNA contribute to disentangle the Afro-Asiatic querelle?
by: L. Castri, et al.
Published: (2012-11-01)

Role of Hypoxia in the Control of the Cell Cycle
by: Jimena Druker, et al.
Published: (2021-05-01)

Complete inhibition of phosphatase and tensin homolog promotes the normal and oxygen-glucose deprivation/reperfusion-injured PC12 cells to cell death
by: Sohrab Minaei Beyrami, et al.
Published: (2018-06-01)

Neuroprotective mechanisms of Asiatic acid
by: Liuyun Ding, et al.
Published: (2023-05-01)

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1α–IL-8–Akt axis
by: Maoyun Fei, et al.
Published: (2018-09-01)

Resveratrol Regulates Glucose and Lipid Metabolism in Diabetic Rats by Inhibition of PDK1/AKT Phosphorylation and HIF-1α Expression
by: Li S, et al.
Published: (2023-04-01)

Haemangiosarcoma in a captive Asiatic lion (Panthera leo persica)
by: F. Vercammen, et al.
Published: (2015-05-01)

Preparation, Characterization and Permeation Study of Topical Gel Loaded with Transfersomes Containing Asiatic Acid
by: Shakthi Apsara Thejani Opatha, et al.
Published: (2022-07-01)

Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes
by: Vinayagam Ramachandran, et al.
Published: (2013-07-01)

EARLY STATE: ASIATIC MODE OF PRODUCTION
by: MARIAM KHANZADYAN
Published: (2019-01-01)

Asiatic acid increased locomotor and head width through inducing brain-derived neurotrophic factor in intrauterine hypoxia-exposed zebrafish
by: Ariani Ariani, et al.
Published: (2023-10-01)

Two sides of the coin: “Asiatic other” Russians vs. “supreme European” Germans?
by: Melih Demirtaş
Published: (2021-06-01)

Choline Inhibits Ischemia-Reperfusion-Induced Cardiomyocyte Autophagy in Rat Myocardium by Activating Akt/mTOR Signaling
by: Pengzhou Hang, et al.
Published: (2018-03-01)

Immunomodulatory and Anti-inflammatory Effects of Asiatic Acid in a DNCB-Induced Atopic Dermatitis Animal Model
by: Gyo-Ha Moon, et al.
Published: (2021-07-01)

Structural Analysis of Metabolites of Asiatic Acid and Its Analogue Madecassic Acid in Zebrafish Using LC/IT-MSn
by: Binbin Xia, et al.
Published: (2015-02-01)

Development of Effervescent Cleansing Tablets Containing Asiatic-Acid-Loaded Solid Lipid Microparticles
by: Lucy Mang Sung Thluai, et al.
Published: (2023-10-01)

Antimicrobial Effect of Asiatic Acid Against Clostridium difficile Is Associated With Disruption of Membrane Permeability
by: Phurt Harnvoravongchai, et al.
Published: (2018-09-01)

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria
by: Hongqun Ding, et al.
Published: (2018-06-01)

Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling
by: Koulong Zheng, et al.
Published: (2018-11-01)

Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis
by: Hongbo Teng, et al.
Published: (2023-11-01)

Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies
by: Zarina Mushtaq, et al.
Published: (2023-09-01)

HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells
by: Nabendu Pore, et al.
Published: (2006-11-01)

Probing Pharmaceutical Strategies to Promote the Skin Delivery of Asiatic Acid from Hydrogels: Enhancement Effects of Organic Amine Counterions, Chemical Enhancers, and Microneedle Pretreatment
by: Mingming Li, et al.
Published: (2022-11-01)

Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway
by: Jieyu Liu, et al.
Published: (2021-11-01)

The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation
by: Yumei Liao, et al.
Published: (2023-03-01)

Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophagy-Mediated HIF-1α/BNIP3 Pathway
by: Na Zhu, et al.
Published: (2020-03-01)

Habitat selection by Asiatic black bear (Ursus thibetanus) in Siran and Kaghan Valleys, Pakistan
by: Z. Ullah, et al.
Published: (2021-08-01)

Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria
by: Tiancong Wu, et al.
Published: (2017-01-01)

Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways
by: Wensheng Zhao, et al.
Published: (2019-01-01)

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways
by: Guoju Hong, et al.
Published: (2020-03-01)

Comparative Analysis of Microbiome Metagenomics in Reintroduced Wild Horses and Resident Asiatic Wild Asses in the Gobi Desert Steppe
by: Liping Tang, et al.
Published: (2022-06-01)

Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo
by: Ya-Hui Chen, et al.
Published: (2023-01-01)