Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan.

Alpha-dystroglycan (α-DG) is a ubiquitously expressed receptor for extracellular matrix proteins and some viruses, and plays a pivotal role in a number of pathological events, including cancer progression, muscular dystrophies, and viral infection. The O-glycans on α-DG are essential for its ligand...

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Détails bibliographiques
Auteurs principaux: Yihong Hu, Zhi-fang Li, Xiaohua Wu, Qilong Lu
Format: Article
Langue:English
Publié: Public Library of Science (PLoS) 2011-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC3036717?pdf=render