CNS-Sparing Histamine H<sub>3</sub> Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms

CNS-Sparing Histamine H<sub>3</sub> Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms

Among the histamine receptors, growing evidence points to the histamine H<sub>3</sub> receptor as a pharmacological candidate to counteract the autonomic neuropathy associated with diabetes. The study aimed to evaluate the effect of PF00868087 (also known as ZPL-868), a CNS-sparing hista...

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Bibliographic Details
Main Authors: Arianna Carolina Rosa, Patrizia Nardini, Silvia Sgambellone, Maura Gurrieri, Simona Federica Spampinato, Alfonso Dell’Accio, Paul L Chazot, Ilona Obara, Wai L Liu, Alessandro Pini
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
histamine
PF0086087
ZPL-868
diabetes
gastrointestinal neuropathy
Online Access:https://www.mdpi.com/2218-273X/12/2/184

Internet

https://www.mdpi.com/2218-273X/12/2/184

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