Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway

Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway

Background and Aim: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway plays a crucial role in autophagy and inflammation. Our previous studies demonstrated that Shen-Yuan-Dan Capsule (SYDC), a Chinese medicine used for treating angina pectori...

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Bibliographic Details
Main Authors: Mingxue Zhou, Pan Ren, Ying Zhang, Sinai Li, Mengjie Li, Ping Li, Juju Shang, Weihong Liu, Hongxu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
foam cells
autophagy
PI3K/Akt/mTORC1
inflammation
Shen-Yuan-Dan Capsule
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00603/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00603/full

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