Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas

Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas

Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to c...

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Bibliographic Details
Main Authors: Meagan B. Myers, Malathi Banda, Karen L. McKim, Yiying Wang, Michael J. Powell, Barbara L. Parsons
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616000282

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http://www.sciencedirect.com/science/article/pii/S1476558616000282

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