Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins

Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins

Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer. Lysosomal targeting has gained increasing interest in recent...

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Bibliographic Details
Main Authors: Morgane Daurat, Corentin Gauthier, Khaled El Cheikh, Lamiaa M. A. Ali, Elodie Morère, Nadir Bettache, Magali Gary-Bobo, Alain Morère, Marcel Garcia, Marie Maynadier, Ilaria Basile
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
therapeutic antibodies
targeted protein degradation
mannose 6-phosphate receptor
M6Pn
immune diseases
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1273280/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1273280/full

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