A network-guided protocol to discover susceptibility genes in genome-wide association studies using stability selection

Summary: We present a network-based protocol to discover susceptibility genes in case-control genome-wide association studies (GWASs). In short, this protocol looks for biomarkers that are informative of disease status and interconnected in an underlying biological network. This boosts discovery and...

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Bibliographic Details
Main Authors: Héctor Climente-González, Chloé-Agathe Azencott, Makoto Yamada
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722008784