Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats

Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats

Rheumatoid arthritis (RA) has a high prevalence in patients with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. To address this, our study established a rat model with both NAFLD and RA by feeding a high-fat diet (HFD) and administering intradermal injection...

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Bibliographic Details
Main Authors: Shengpeng Zhang, Peng Zhu, Jianan Yuan, Kunming Cheng, Qixiang Xu, Wei Chen, Zui Pan, Yongqiu Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
non-alcoholic fatty liver disease
rheumatoid arthritis
polymerase I and transcript release factor
TLR4
PTRF
PI3K/AKT signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1149665/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1149665/full

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