DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE

DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE

α-synuclein is one of the key molecular links in the pathogenesis of Parkinson’s disease. The accumulated data indicate that pathogenic mutations in the Snca gene are associated with the development of neurodegenerative brain damage, indicating the relevance of studying the synuclein neurobiological...

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Bibliographic Details
Main Authors: E. A. Patrakhanov, V. M. Pokrovsky, A. Yu. Karagodina, A. M. Krayushkina, N. S. Zhunusov, A. V. Deykin, M. V. Korokin, M. V. Pokrovsky, O. B. Altukhova
Format: Article
Language:Russian
Published: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute 2023-02-01
Series:Фармация и фармакология (Пятигорск)
Subjects:
α-synuclein
neurodegeneration
parkinson’s disease
conditional knockout
crispr/cas9
Online Access:https://www.pharmpharm.ru/jour/article/view/1218

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