Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D4R has also been investigated as a target for antipsychotics due...

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Bibliographic Details
Main Authors: Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Kristoffer Sahlholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
luminescence measurements
luciferase
electrophysiology
HEK 293 cells
Xenopus laevis
G protein-coupled inwardly rectifying potassium channels
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1087171/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1087171/full

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