Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D4R has also been investigated as a target for antipsychotics due...

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Bibliografiska uppgifter
Huvudupphovsmän: Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Kristoffer Sahlholm
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2023-01-01
Serie:Frontiers in Pharmacology
Ämnen:
luminescence measurements
luciferase
electrophysiology
HEK 293 cells
Xenopus laevis
G protein-coupled inwardly rectifying potassium channels
Länkar:https://www.frontiersin.org/articles/10.3389/fphar.2023.1087171/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1087171/full

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