The Mechanism of Enantioselective Neurosteroid Actions on GABA<sub>A</sub> Receptors

The Mechanism of Enantioselective Neurosteroid Actions on GABA<sub>A</sub> Receptors

The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABA<sub>A</sub> receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not. This study was aimed at determ...

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Bibliographic Details
Main Authors: Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
neurosteroids
GABA-A receptors
enantiomers
photolabeling
Online Access:https://www.mdpi.com/2218-273X/13/2/341

Internet

https://www.mdpi.com/2218-273X/13/2/341

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