Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets
A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pu...
| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
The Company of Biologists
2016-09-01
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| coleção: | Disease Models & Mechanisms |
| Assuntos: | |
| Acesso em linha: | http://dmm.biologists.org/content/9/9/1039 |